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Value & Access

Value Strategy and Economic Case to Secure U.S. for a Novel CNS Therapy

image of pharmacy community engagement activities
Client Profile

Small MedTech

Key Stakeholders

Reimbursement, Medical Affairs, Clinical, Marketing

Asset

Launched

Disease Area

Central Nervous System Disorders

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Client Profile

Small MedTech

Key Stakeholders

Reimbursement, Medical Affairs, Clinical, Marketing

Asset

Launched

Disease Area

Central Nervous System Disorders

Situation

A small medtech company had launched a new non-pharmacological treatment for patients with treatment-resistant depression.

While clinical promise was strong, establishing medical necessity and securing payer coverage required a clear articulation of burden, unmet need, and economic impact.

The client engaged Alkemi to define a payer-relevant value story and develop tools to support U.S. coverage discussions.

Approach

1. Conducted targeted literature review to assess disease burden, current treatment outcomes, and areas of unmet need.

2. Facilitated a cross-functional workshop to prioritize payer-relevant value messages across clinical, economic, and humanistic domains.

3. Developed a budget impact model to quantify economic implications and validated assumptions with thought leaders.

4. Created a payer-facing value deck to communicate burden, unmet need, and economic impact.

The focus throughout:

Clarify what matters most to payers and demonstrate impact with credible data.

Deliverables

1
Targeted literature review mapping burden and unmet need.
2
Value story workshop to align on priority payer messages.
3
Budget impact model validated through expert interviews.
4
Payer value deck articulating clinical and economic impact.
5
6

Impact

"This work helped us get clear on what really mattered to payers and how to talk about it." - Marketing Leader

Stronger Payer Positioning:

Aligned internal teams on the value drivers most relevant to U.S. payers.

Credible Economic Justification:

Validated budget impact model strengthened discussions with coverage decision-makers.

Secured Coverage:

The value deck and economic model were used in CMS discussions that resulted in national outpatient coverage.

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